It is possible to wire this controller so a spindle can be turned on and off, but spindle speed would not be possible and would need to be controlled from the control panel. It is not recommended to use a laser controller to control a spindle as a laser controller is specifically made for lasers to control speed and intensity. A traditional CNC controller is best to be mated with a system that uses a spindle as there are more sophisticated machining operations that take into consideration the features of a tool (end mill, drill, surfacing tool, etc.).
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I would recommend creating a system, similar to the greenBull, where there are two gantries on a single table where one gantry houses a spindle and the other gantry houses a laser. Each gantry can use a disparate controller, but be mapped/calibrated/aligned to the same surface.
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[521] Can this be used to control a spindle as well as a laser?